Synthetic Studies on Human Insulin-Like Growth Factor I

Katsoyannis, Panayotis G.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK029988-08
• Application #: 3229191
• Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)
• Project Start: 1987-09-01
• Project End: 1990-08-31
• Budget Start: 1989-09-01
• Budget End: 1990-08-31
• Support Year: 8
• Fiscal Year: 1989

Institution

• Name: Mount Sinai School of Medicine
• Type: Schools of Medicine
• City: New York
• State: NY
• Country: United States
• Zip Code: 10029

Publications

Joshi, S; Burke, G T; Katsoyannis, P G (1990) An insulin-like compound consisting of the B-chain of bovine insulin and an A-chain corresponding to a modified A- and the D-domains of human insulin-like growth factor I. J Protein Chem 9:235-46

Zong, L; Burke, G T; Katsoyannis, P G (1990) An insulin-like hybrid consisting of a modified A-domain of human insulin-like growth factor I and the B-chain of insulin. J Protein Chem 9:389-95

Chen, Z Z; Schwartz, G P; Zong, L et al. (1988) Determinants of growth-promoting activity reside in the A-domain of insulin-like growth factor I. Biochemistry 27:6105-11

Tseng, L Y; Schwartz, G P; Sheikh, M et al. (1987) Hybrid molecules containing the A-domain of insulin-like growth factor-I and the B-chain of insulin have increased mitogenic activity relative to insulin. Biochem Biophys Res Commun 149:672-9