Regulation of the Activity of the Urea Cycle

Powers-Lee, Susan G.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK033460-12
• Application #: 2139053
• Study Section: Medical Biochemistry Study Section (MEDB)
• Project Start: 1984-07-01
• Project End: 1996-11-30
• Budget Start: 1994-07-01
• Budget End: 1996-11-30
• Support Year: 12
• Fiscal Year: 1994

Institution

• Name: Northeastern University
• Department: Biology
• Type: Schools of Arts and Sciences
• DUNS #: 039318308
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02115

Publications

Kothe, M; Eroglu, B; Mazza, H et al. (1997) Novel mechanism for carbamoyl-phosphate synthetase: a nucleotide switch for functionally equivalent domains. Proc Natl Acad Sci U S A 94:12348-53

Zheng, W; Lim, A L; Powers-Lee, S G (1997) Identification of critical amino acid residues of Saccharomyces cerevisiae carbamoyl-phosphate synthetase: definition of the ATP site involved in carboxy-phosphate formation. Biochim Biophys Acta 1341:35-48

Lim, A L; Powers-Lee, S G (1997) Critical roles for arginine 1061/1060 and tyrosine 1057 in Saccharomyces cerevisiae arginine-specific carbamoyl-phosphate synthetase. Arch Biochem Biophys 339:344-52

Lim, A L; Powers-Lee, S G (1996) Requirement for the carboxyl-terminal domain of Saccharomyces cerevisiae carbamoyl-phosphate synthetase. J Biol Chem 271:11400-9

McCudden, C R; Powers-Lee, S G (1996) Required allosteric effector site for N-acetylglutamate on carbamoyl-phosphate synthetase I. J Biol Chem 271:18285-94

Potter, M D; Powers-Lee, S G (1993) Direct photoaffinity labeling of rat liver carbamoyl phosphate synthetase I with ATP. Arch Biochem Biophys 306:377-82

Potter, M D; Powers-Lee, S G (1992) Location of the ATP gamma-phosphate-binding sites on rat liver carbamoyl-phosphate synthetase I. Studies with the ATP analog 5'-p-fluorosulfonylbenzoyladenosine. J Biol Chem 267:2023-31

Brandt, M A; Powers-Lee, S G (1991) The interaction of cardiolipin with rat liver carbamoyl phosphate synthetase I. Arch Biochem Biophys 290:14-20