Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK033873-08S1
Application #
3232271
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1988-01-01
Project End
1992-12-31
Budget Start
1992-01-01
Budget End
1992-12-31
Support Year
8
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Lernmark, A; Kloppel, G; Stenger, D et al. (1995) Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus. Virchows Arch 425:631-40
Li, L; Hagopian, W A; Brashear, H R et al. (1994) Identification of autoantibody epitopes of glutamic acid decarboxylase in stiff-man syndrome patients. J Immunol 152:930-4
Grubin, C E; Daniels, T; Toivola, B et al. (1994) A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 37:344-50
Lernmark, A (1994) Molecular biology of IDDM. Diabetologia 37 Suppl 2:S73-81
Hagopian, W A; Karlsen, A E; Gottsater, A et al. (1993) Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type. J Clin Invest 91:368-74
Landin-Olsson, M; Palmer, J P; Lernmark, A et al. (1992) Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children. Diabetologia 35:1068-73
Barmeier, H; Ahlmen, J; Landin-Olsson, M et al. (1992) Quantitative analysis of islet glutamic acid decarboxylase p64 autoantibodies in insulin-dependent diabetes mellitus. Autoimmunity 13:187-96
Pollema, C H; Ruzicka, J; Christian, G D et al. (1992) Sequential injection immunoassay utilizing immunomagnetic beads. Anal Chem 64:1356-61
Karlsen, A E; Hagopian, W A; Petersen, J S et al. (1992) Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-M(r) autoantibodies. Diabetes 41:1355-9
Barmeier, H; McCulloch, D K; Neifing, J L et al. (1991) Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies. Diabetologia 34:727-33

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