Correct Pairing of Insulin a and B Chains in Solution

Tsou, Chen-Lu

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK034035-06
• Application #: 2139211
• Study Section: Biophysics and Biophysical Chemistry B Study Section (BBCB)
• Project Start: 1984-08-01
• Project End: 1990-07-31
• Budget Start: 1989-09-30
• Budget End: 1990-07-31
• Support Year: 6
• Fiscal Year: 1989

Institution

• Name: Institute of Biophysics
• City: Beijing
• Country: China

Publications

Tang, J G; Tsou, C L (1990) The insulin A and B chains contain structural information for the formation of the native molecule. Studies with protein disulphide-isomerase. Biochem J 268:429-35

Hua, Q X (1989) H spin system identifications of S-sulfonated insulin B chain with 2D-NMR. Sci China B 32:948-59

Hua, Q X; Chen, Y J; Wang, C C et al. (1989) High resolution 1H-NMR studies of Des-(B26-B30)-insulin;assignment of resonances and properties of aromatic residues. Biochim Biophys Acta 994:114-20

Tsou, C L (1988) Folding of the nascent peptide chain into a biologically active protein. Biochemistry 27:1809-12

Tang, J G; Wang, C C; Tsou, C L (1988) Formation of native insulin from the scrambled molecule by protein disulphide-isomerase. Biochem J 255:451-5

Qian, Y Q; Tsou, C L (1987) Resynthesis of insulin from its A and B chains in the presence of denaturants. Biochem Biophys Res Commun 146:437-42

Tian, Y; Wang, C C; Tsou, C L (1987) Interaction and combination of separate A and B chains of insulin effects of D-and L-tryptophan in position A1. Biol Chem Hoppe Seyler 368:397-403