Abstract

This research project is concerned with the factors regulating the secretion and function of thyrotrophin releasing hormone (TRH) and other related hypothalamic releasing hormones and neural peptides from the diffuse neuroendocrine system of vertebrate species, including man. The influence of physiologic stimuli, neurotransmitters, endocrine status and other factors on TRH secretion will be examined using a variety of in vivo and in vitro techniques. The functional implication of the anatomic and phylogenetic distribution of TRH, luteinizing hormone releasing hormone (LH-RH) and other hypophysiotrophic factors and neural peptides will be investigated. Experiments are being undertaken utilizing various chemical and immunologic techniques to characterize the nature of these neural peptides in neuronal and non-neuronal tissues of different species.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK034540-04
Application #
3232848
Study Section
Endocrinology Study Section (END)
Project Start
1984-03-01
Project End
1988-11-30
Budget Start
1986-09-01
Budget End
1988-11-30
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Rhode Island Hospital (Providence, RI)
Department
Type
DUNS #
161202122
City
Providence
State
RI
Country
United States
Zip Code
02903

  Publications

Bruhn, T O; Rondeel, J M; Bolduc, T G et al. (1995) Thyrotropin-releasing hormone gene expression in cultured anterior pituitary cells: role of gender. Neuroendocrinology 61:77-84
Bruhn, T O; Rondeel, J M; Bolduc, T G et al. (1994) Thyrotropin-releasing hormone gene expression in the anterior pituitary. III. Stimulation by thyroid hormone: potentiation by glucocorticoids. Endocrinology 134:826-30
Bruhn, T O; Bolduc, T G; Rondeel, J M et al. (1994) Thyrotropin-releasing hormone gene expression in the anterior pituitary. II. Stimulation by glucocorticoids. Endocrinology 134:821-5
Bruhn, T O; Rondeel, J M; Bolduc, T G et al. (1994) Thyrotropin-releasing hormone (TRH) gene expression in the anterior pituitary. I. Presence of pro-TRH messenger ribonucleic acid and pro-TRH-derived peptide in a subpopulation of somatotrophs. Endocrinology 134:815-20
McFarlane, M B; Bruhn, T O; Jackson, I M (1993) Postsomatostatin hypersecretion of growth hormone from perifused rat anterior pituitary cells is dependent on calcium influx. Neuroendocrinology 57:496-502
Nillni, E A; Sevarino, K A; Jackson, I M (1993) Identification of the thyrotropin-releasing hormone-prohormone and its posttranslational processing in a transfected AtT20 tumoral cell line. Endocrinology 132:1260-70
Nillni, E A; Sevarino, K A; Jackson, I M (1993) Processing of proTRH to its intermediate products occurs before the packing into secretory granules of transfected AtT20 cells. Endocrinology 132:1271-7
Bruhn, T O; McFarlane, M B; Deckey, J E et al. (1992) Analysis of pulsatile secretion of thyrotropin and growth hormone in the hypothyroid rat. Endocrinology 131:2615-21
Bruhn, T O; Jackson, I M (1992) Abnormalities of the thyroid hormone negative feedback regulation of TSH secretion in spontaneously hypertensive rats. Regul Pept 38:221-30
Bruhn, T O; Taplin, J H; Jackson, I M (1991) Hypothyroidism reduces content and increases in vitro release of pro-thyrotropin-releasing hormone peptides from the median eminence. Neuroendocrinology 53:511-5

Showing the most recent 10 out of 28 publications