Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK034806-06
Application #
2139378
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1985-09-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Pathology
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Jones, Juliet A; Kaphalia, Lata; Treinen-Moslen, Mary et al. (2003) Proteomic characterization of metabolites, protein adducts, and biliary proteins in rats exposed to 1,1-dichloroethylene or diclofenac. Chem Res Toxicol 16:1306-17
Atchison, C R; West, A B; Balakumaran, A et al. (2000) Drug enterocyte adducts: possible causal factor for diclofenac enteropathy in rats. Gastroenterology 119:1537-47
Atchison, C R; Balakumaran, A; West, A B et al. (2000) Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy. Dig Dis Sci 45:614-20
Kanz, M F; Gunasena, G H; Kaphalia, L et al. (1998) A minimally toxic dose of methylene dianiline injures biliary epithelial cells in rats. Toxicol Appl Pharmacol 150:414-26
Woodard, S H; Moslen, M T (1998) Decreased biliary secretion of proteins and phospholipids by rats with 1,1-dichloroethylene-induced bile canalicular injury. Toxicol Appl Pharmacol 152:295-301
Moslen, M T; Kanz, M F; Bhatia, J et al. (1994) Biliary glutathione and some amino acids are markedly diminished when biliary pressure is elevated. Exp Mol Pathol 61:1-15
Moslen, M T; Kanz, M F (1993) Biliary excretion of marker solutes by rats with 1,1-dichloroethylene-induced bile canalicular injury. Toxicol Appl Pharmacol 122:117-30
Moslen, M T; Kanz, M F; Bhatia, J et al. (1992) Biliary endogenous inorganic phosphate, D-glucose, IgA and transferrin are differentially altered by hydrostatic pressure. J Hepatol 16:89-97
Kanz, M F; Whitehead, R F; Ferguson, A E et al. (1992) Biliary function studies during multiple time periods in freely moving rats. A useful system and set of marker solutes. J Pharmacol Toxicol Methods 27:7-15
Kanz, M F; Taj, Z; Moslen, M T (1991) 1,1-Dichloroethylene hepatotoxicity: hypothyroidism decreases metabolism and covalent binding but not injury in the rat. Toxicology 70:213-29

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