Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK035083-10
Application #
2139475
Study Section
Endocrinology Study Section (END)
Project Start
1987-08-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sidney Kimmel Cancer Center
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92121
Piedrafita, F J; Pfahl, M (1997) Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation. Mol Cell Biol 17:6348-58
Piedrafita, F J; Ortiz, M A; Pfahl, M (1995) Thyroid hormone receptor-beta mutants associated with generalized resistance to thyroid hormone show defects in their ligand-sensitive repression function. Mol Endocrinol 9:1533-48
Piedrafita, F J; Bendik, I; Ortiz, M A et al. (1995) Thyroid hormone receptor homodimers can function as ligand-sensitive repressors. Mol Endocrinol 9:563-78
Bendik, I; Pfahl, M (1995) Similar ligand-induced conformational changes of thyroid hormone receptors regulate homo- and heterodimeric functions. J Biol Chem 270:3107-14
Hermann, T; Hoffmann, B; Piedrafita, F J et al. (1993) V-erbA requires auxiliary proteins for dominant negative activity. Oncogene 8:55-65
Pfahl, M (1993) Nuclear receptor/AP-1 interaction. Endocr Rev 14:651-8
Tran, P; Zhang, X K; Salbert, G et al. (1992) COUP orphan receptors are negative regulators of retinoic acid response pathways. Mol Cell Biol 12:4666-76
Hermann, T; Hoffmann, B; Zhang, X K et al. (1992) Heterodimeric receptor complexes determine 3,5,3'-triiodothyronine and retinoid signaling specificities. Mol Endocrinol 6:1153-62
Graupner, G; Malle, G; Maignan, J et al. (1991) 6'-substituted naphthalene-2-carboxylic acid analogs, a new class of retinoic acid receptor subtype-specific ligands. Biochem Biophys Res Commun 179:1554-61
Haq, R; Pfahl, M; Chytil, F (1991) Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats. Proc Natl Acad Sci U S A 88:8272-6

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