Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK035397-04S1
Application #
3233713
Study Section
Metabolism Study Section (MET)
Project Start
1985-09-20
Project End
1991-08-31
Budget Start
1988-12-01
Budget End
1989-08-31
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Knutson, V P; Donnelly, P V; Balba, Y et al. (1995) Insulin resistance is mediated by a proteolytic fragment of the insulin receptor. J Biol Chem 270:24972-81
Milton, S G; Knutson, V P (1993) Insulin receptor characterization and function in bovine aorta endothelial cells: insulin degradation by a plasma membrane, protease-resistant insulin receptor. J Cell Physiol 157:333-43
Knutson, V P (1992) Ligand-independent internalization and recycling of the insulin receptor. Effects of chronic treatment of 3T3-C2 fibroblasts with insulin and dexamethasone. J Biol Chem 267:931-7
Knutson, V P (1991) Proteolytic processing of the insulin receptor beta subunit is associated with insulin-induced receptor down-regulation. J Biol Chem 266:15656-62
Knutson, V P; Buck, R A (1991) Comparison of insulin receptor tyrosine phosphorylation under in vitro and in situ conditions: assessment of specific protein tyrosine phosphorylation without the use of 32P-phosphate-labeled substrates. Arch Biochem Biophys 285:197-204
Knutson, V P; Buck, R A; Moreno, R M (1991) Purification of a murine monoclonal antibody of the IgM class. J Immunol Methods 136:151-7
Knutson, V P (1991) Cellular trafficking and processing of the insulin receptor. FASEB J 5:2130-8
Milton, S G; Knutson, V P (1990) Comparison of the function of the tight junctions of endothelial cells and epithelial cells in regulating the movement of electrolytes and macromolecules across the cell monolayer. J Cell Physiol 144:498-504