Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK035808-01S1
Application #
3234065
Study Section
Metabolism Study Section (MET)
Project Start
1985-12-01
Project End
1988-08-31
Budget Start
1985-12-01
Budget End
1986-08-31
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Bryla, J; Michalik, M; Nelson, J et al. (1994) Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and its consequence on insulin release. Metabolism 43:1187-95
Michalik, M; Nelson, J; Erecinska, M (1993) GABA production in rat islets of Langerhans. Diabetes 42:1506-13
Ohta, M; Nelson, J; Nelson, D et al. (1993) Effect of Ca++ channel blockers on energy level and stimulated insulin secretion in isolated rat islets of Langerhans. J Pharmacol Exp Ther 264:35-40
Michalik, M; Nelson, J; Erecinska, M (1992) Glutamate production in islets of Langerhans: properties of phosphate-activated glutaminase. Metabolism 41:1319-26
Ohta, M; Nelson, D; Wilson, J M et al. (1992) Relationships between energy level and insulin secretion in isolated rat islets of Langerhans. Manipulation of [ATP]/[ADP][Pi] by 2-deoxy-D-glucose. Biochem Pharmacol 43:1859-64
Erecinska, M; Bryla, J; Michalik, M et al. (1992) Energy metabolism in islets of Langerhans. Biochim Biophys Acta 1101:273-95
Ohta, M; Nelson, D; Nelson, J et al. (1991) Relationships between energy level and insulin secretion in isolated rat islets of Langerhans. A study at various pH values. Biochem Pharmacol 42:593-8
Thermos, K; Meglasson, M D; Nelson, J et al. (1990) Pancreatic beta-cell somatostatin receptors. Am J Physiol 259:E216-24
Ohta, M; Nelson, D; Nelson, J et al. (1990) Oxygen and temperature dependence of stimulated insulin secretion in isolated rat islets of Langerhans. J Biol Chem 265:17525-32
Meglasson, M D; Smith, K M; Nelson, D et al. (1989) alpha-Glycerophosphate shuttle in a clonal beta-cell line. Am J Physiol 256:E173-8

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