Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036069-11
Application #
2139713
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1985-09-23
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Lesnefsky, Edward J; He, DingChao; Moghaddas, Shadi et al. (2006) Reversal of mitochondrial defects before ischemia protects the aged heart. FASEB J 20:1543-5
Lesnefsky, E J; Gudz, T I; Moghaddas, S et al. (2001) Aging decreases electron transport complex III activity in heart interfibrillar mitochondria by alteration of the cytochrome c binding site. J Mol Cell Cardiol 33:37-47
Lesnefsky, E J; Gudz, T I; Migita, C T et al. (2001) Ischemic injury to mitochondrial electron transport in the aging heart: damage to the iron-sulfur protein subunit of electron transport complex III. Arch Biochem Biophys 385:117-28
Weinberg, G L; Palmer, J W; VadeBoncouer, T R et al. (2000) Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria. Anesthesiology 92:523-8
Lesnefsky, E J; Stoll, M S; Minkler, P E et al. (2000) Separation and quantitation of phospholipids and lysophospholipids by high-performance liquid chromatography. Anal Biochem 285:246-54
Fannin, S W; Lesnefsky, E J; Slabe, T J et al. (1999) Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria. Arch Biochem Biophys 372:399-407
Lesnefsky, E J; Tandler, B; Ye, J et al. (1997) Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria. Am J Physiol 273:H1544-54