Recent evidence obtained in a variety of experimental circumstances suggests that glomerular ultrafiltration and subsequent fluid reclamation by the downstream peritubular capillaries are subject to humoral and neural regulation. The evidence for this previously unrecognized function of hormones and nerves necessitates an intensive investigative effort to determine their roles in the altered glomerular and proximal tubular function seen in many physiological and pathophysiological conditions. Accordingly, this research project is aimed to 1) clarifying further the kinetics of the processes of glomerular filtration and proximal fluid reabsorption and the mechanisms by which hormones and neurotransmitters affect these processes, and 2) identifying the functional roles of hormones in altered fluid filtration and reabsorption in various physiological and pathophysiological conditions. Using in vivo micropuncture techniques, transcapillary Starling forces determining the filtration and reclamation of fluid will be measured during experimentally induced variations in filtration and reabsorption to ascertain the specific sites and modes of alteration in filtration and reabsorption of the glomerular and peritubular microcirculation. Since hemodynamic alterations induced by some vasoactive hormones are potentially capable of increasing the transglomerular passage of macromolecules, a causal relationship between such hormones actions and proteinuria will also be explored. When appropriate, morphometric techniques will be used to correlate structural and functional observations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK037869-03
Application #
3236841
Study Section
General Medicine B Study Section (GMB)
Project Start
1985-12-01
Project End
1991-01-31
Budget Start
1988-02-01
Budget End
1989-01-31
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37203