Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK039348-09
Application #
2140912
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1988-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Brosnan, J T; Brosnan, M E; Charron, R et al. (1997) Incorporation of 15N-labelled precursors into urea isotopomers. Contrib Nephrol 121:156-62
Nissim, I; Weinberg, J M (1996) Glycine attenuates Fanconi syndrome induced by maleate or ifosfamide in rats. Kidney Int 49:684-95
Nissim, I; Yudkoff, M; Brosnan, J T (1996) Regulation of [15N]urea synthesis from [5-15N]glutamine. Role of pH, hormones, and pyruvate. J Biol Chem 271:31234-42
Brosnan, J T; Brosnan, M E; Charron, R et al. (1996) A mass isotopomer study of urea and glutamine synthesis from 15N-labeled ammonia in the perfused rat liver. J Biol Chem 271:16199-207
Tannen, R L; Nissim, I; Sahi, A (1996) Hormonal mediators of ammoniagenesis: mechanism of action of PGF2 alpha and the implications for other hormones. Kidney Int 50:15-25
Nissim, I; States, B; Nissim, I et al. (1995) Hormonal regulation of glutamine metabolism by OK cells. Kidney Int 47:96-105
Foreman, J W; Benson, L L; Wellons, M et al. (1995) Metabolic studies of rat renal tubule cells loaded with cystine: the cystine dimethylester model of cystinosis. J Am Soc Nephrol 6:269-72
Sahai, A; Nissim, I; Sandler, R S et al. (1995) Prostaglandin F2 alpha- and 12-O-tetradecanoylphorbol-13-acetate-induced alterations in the pathways of renal ammoniagenesis. J Am Soc Nephrol 5:1792-8
Nissim, I; States, B; Nissim, I et al. (1994) pH and hormonal regulation of ammoniagenesis in cultured OK cells. Contrib Nephrol 110:30-40
Nissim, I; Sahai, A; Sandler, R S et al. (1994) The intensity of acidosis differentially alters the pathways of ammoniagenesis in LLC-PK1 cells. Kidney Int 45:1014-9

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