In this continuation application, the investigators plan to conduct three studies that include neuropsychological and psychosocial assessments, as well as physical examinations and laboratory measures. The first is a prospective study that tests the hypothesis that the subsequent occurrence (or worsening) of certain biomedical complications will be associated with the development of mild neuropsychological dysfunction. To that end, subjects will be re-evaluated 6 years after their initial assessment when many of them will have developed their first clinically significant biomedical complications, or a worsening of earlier complications. The second study is cross-sectional and is designed to develop a model that explains the complex interactions among microvascular complications, normal aging and its illnesses, chronic hyperglycemia, and neuropsychological processes. To that end, the investigator will recruit from the community groups of younger and older Type 1 diabetic subjects, including those with significant microvascular disease. A major goal of the third study is to determine the etiology for memory disorders in diabetic adults. The investigators have hypothesized that the memory disorders commonly seen in elderly Type 2 diabetic adults (but rarely reported in younger Type 1 diabetic adults) reflect an interaction between chronic hyperglycemia and aging. A group of younger and older Type 2 diabetic adults will be recruited and compare their memory skills will be compared to younger and older Type 1 diabetic adults recruited from the community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK039629-09
Application #
2634211
Study Section
Behavioral Medicine Study Section (BEM)
Program Officer
Garfield, Sanford A
Project Start
1988-03-01
Project End
1998-12-31
Budget Start
1998-02-01
Budget End
1998-12-31
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Rosario, Bedda L; Ziolko, Scott K; Weissfeld, Lisa A et al. (2008) Assessment of parameter settings for SPM5 spatial normalization of structural MRI data: application to type 2 diabetes. Neuroimage 41:363-70
Ryan, C M; Geckle, M O; Orchard, T J (2003) Cognitive efficiency declines over time in adults with Type 1 diabetes: effects of micro- and macrovascular complications. Diabetologia 46:940-8
Morrow, Lisa A; Ryan, Christopher (2002) Normative data for a working memory test: the four word short-term memory test. Clin Neuropsychol 16:373-80
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Ryan, C M; Becker, D J (1999) Hypoglycemia in children with type 1 diabetes mellitus. Risk factors, cognitive function, and management. Endocrinol Metab Clin North Am 28:883-900
Ryan, C M; Williams, T M; Finegold, D N et al. (1993) Cognitive dysfunction in adults with type 1 (insulin-dependent) diabetes mellitus of long duration: effects of recurrent hypoglycaemia and other chronic complications. Diabetologia 36:329-34
Ryan, C M; Williams, T M (1993) Effects of insulin-dependent diabetes on learning and memory efficiency in adults. J Clin Exp Neuropsychol 15:685-700
Ryan, C M; Williams, T M; Orchard, T J et al. (1992) Psychomotor slowing is associated with distal symmetrical polyneuropathy in adults with diabetes mellitus. Diabetes 41:107-13