Abstract

Preliminary research conducted by the applicants indicates that over 40% of nonalcoholic patients with chronic cholestatic liver disease demonstrate a clinically significant vitamin E deficiency. The severity of deficiency has additionally been found to covary with neurologic impairment and quantitative measures of psychomotor deficit. This study will further evaluate the extent to which vitamin E deficiency occurs in a variety of liver diseases and its relationship to the severity of liver injury. Furthermore, the proposed investigation also aims to evaluate the extent to which this vitamin deficiency can be ameliorated following a course of vitamin E supplementation. Concomitant to vitamin E treatment, recovery of neurologic function and psychomotor capacity will be monitored and measured. The findings obtained from this investigation will help clarify the multifactorial etiology of hepatic encephalopathy and improve the medical management of patients with chronic liver disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK039789-03
Application #
3239789
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1989-01-01
Project End
1992-12-31
Budget Start
1991-01-01
Budget End
1991-12-31
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Hassanein, T; Colantoni, A; De Maria, N et al. (1996) Interferon-alpha 2b improves short-term survival in patients transplanted for chronic liver failure caused by hepatitis B. J Viral Hepat 3:333-40
Caraceni, P; Ryu, H S; van Thiel, D H et al. (1995) Source of oxygen free radicals produced by rat hepatocytes during postanoxic reoxygenation. Biochim Biophys Acta 1268:249-54
Caraceni, P; Rosenblum, E R; Van Thiel, D H et al. (1994) Reoxygenation injury in isolated rat hepatocytes: relation to oxygen free radicals and lipid peroxidation. Am J Physiol 266:G799-806
Sakr, M F; McClain, C J; Gavaler, J S et al. (1993) FK 506 pre-treatment is associated with reduced levels of tumor necrosis factor and interleukin 6 following hepatic ischemia/reperfusion. J Hepatol 17:301-7
Rabinovitz, M; Prieto, M; Gavaler, J S et al. (1992) Bacteriuria in patients with cirrhosis. J Hepatol 16:73-6
Van Thiel, D H; Finkel, R; Friedlander, L et al. (1992) The association of IgA deficiency but not IgG or IgM deficiency with a reduced patient and graft survival following liver transplantation. Transplantation 54:269-73
Sakr, M F; Zetti, G M; Farghali, H et al. (1991) Protective effect of FK 506 against hepatic ischemia in rats. Transplant Proc 23:340-1
Arria, A M; Tarter, R E; Kabene, M A et al. (1991) The role of cirrhosis in memory functioning of alcoholics. Alcohol Clin Exp Res 15:932-7
Arria, A M; Tarter, R E; Starzl, T E et al. (1991) Improvement in cognitive functioning of alcoholics following orthotopic liver transplantation. Alcohol Clin Exp Res 15:956-62
Sakr, M F; Zetti, G M; Hassanein, T I et al. (1991) FK 506 ameliorates the hepatic injury associated with ischemia and reperfusion in rats. Hepatology 13:947-51

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