Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK040698-09
Application #
2357180
Study Section
Pathology A Study Section (PTHA)
Project Start
1989-01-01
Project End
1999-03-31
Budget Start
1996-05-01
Budget End
1997-03-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Li, Xiaohong; Li, Hsi-Ping; Amsler, Kurt et al. (2002) PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis. Proc Natl Acad Sci U S A 99:9260-5
Lasker, J M; Chen, W B; Wolf, I et al. (2000) Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. J Biol Chem 275:4118-26
Geng, L; Burrow, C R; Li, H P et al. (2000) Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation. Biochim Biophys Acta 1535:21-35
Wilson, P D; Geng, L; Li, X et al. (1999) The PKD1 gene product, ""polycystin-1,"" is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia. Lab Invest 79:1311-23
Wilson, P D; Guay-Woodford, L (1999) Pathophysiology and clinical management of polycystic kidney disease in women. Semin Nephrol 19:123-32
Hartz, P A; Wilson, P D (1997) Functional defects in lysosomal enzymes in autosomal dominant polycystic kidney disease (ADPKD): abnormalities in synthesis, molecular processing, polarity, and secretion. Biochem Mol Med 60:8-26
Kuo, N T; Norman, J T; Wilson, P D (1997) Acidic FGF regulation of hyperproliferation of fibroblasts in human autosomal dominant polycystic kidney disease. Biochem Mol Med 61:178-91
Wilson, P D (1997) Epithelial cell polarity and disease. Am J Physiol 272:F434-42
Du, J; Wilson, P D (1995) Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD. Am J Physiol 269:C487-95
Wilson, P D; Du, J; Norman, J T (1993) Autocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease. Eur J Cell Biol 61:131-8

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