Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK040725-09
Application #
2141454
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1988-04-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wayne State University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Lash, L H (2011) Renal membrane transport of glutathione in toxicology and disease. Vet Pathol 48:408-19
Zhong, Qing; Putt, David A; Xu, Feng et al. (2008) Hepatic mitochondrial transport of glutathione: studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells. Arch Biochem Biophys 474:119-27
Lash, Lawrence H; Putt, David A; Xu, Feng et al. (2007) Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione. Chem Biol Interact 170:124-34
Donahue, Ashley N; Aschner, Michael; Lash, Lawrence H et al. (2006) Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus. Mech Ageing Dev 127:57-63
Lash, Lawrence H; Putt, David A; Zalups, Rudolfs K (2006) Influence of compensatory renal growth on susceptibility of primary cultures of renal cells to chemically induced injury. Toxicol Sci 94:417-27
Xu, Feng; Putt, David A; Matherly, Larry H et al. (2006) Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis. J Pharmacol Exp Ther 316:1175-86
Lash, Lawrence H (2006) Mitochondrial glutathione transport: physiological, pathological and toxicological implications. Chem Biol Interact 163:54-67
Lash, Lawrence H (2005) Role of glutathione transport processes in kidney function. Toxicol Appl Pharmacol 204:329-42
Lash, Lawrence H; Hueni, Sarah E; Putt, David A et al. (2005) Role of organic anion and amino acid carriers in transport of inorganic mercury in rat renal basolateral membrane vesicles: influence of compensatory renal growth. Toxicol Sci 88:630-44
Lash, Lawrence H; Putt, David A; Matherly, Larry H (2002) Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter. J Pharmacol Exp Ther 303:476-86

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