Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041009-04
Application #
3241556
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1989-02-01
Project End
1994-01-31
Budget Start
1992-02-01
Budget End
1993-01-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Hauptman-Woodward Medical Research Institute
Department
Type
DUNS #
074025479
City
Buffalo
State
NY
Country
United States
Zip Code
14203
Wojtczak, A; Cody, V; Luft, J R et al. (2001) Structure of rat transthyretin (rTTR) complex with thyroxine at 2.5 A resolution: first non-biased insight into thyroxine binding reveals different hormone orientation in two binding sites. Acta Crystallogr D Biol Crystallogr 57:1061-70
Cody, V; Wojtczak, A; Davis, F B et al. (1995) Structure-activity relationships of milrinone analogues determined in vitro in a rabbit heart membrane Ca(2+)-ATPase model. J Med Chem 38:1990-7
Rosen, H N; Murrell, J R; Liepnieks, J J et al. (1994) Threonine for alanine substitution at position 109 of transthyretin differentially alters human transthyretin's affinity for iodothyronines. Endocrinology 134:27-34
Kragie, L; Forrester, M L; Cody, V et al. (1994) Computer-assisted molecular modeling of benzodiazepine and thyromimetic inhibitors of the HepG2 iodothyronine membrane transporter. Mol Endocrinol 8:382-91
Wojtczak, A; Luft, J R; Cody, V (1993) Structural aspects of inotropic bipyridine binding. Crystal structure determination to 1.9 A of the human serum transthyretin-milrinone complex. J Biol Chem 268:6202-6
Wallet, J C; Cody, V; Wojtczak, A et al. (1993) Structural and conformational studies on bio-active flavonoids. Crystal and molecular structure of a complex formed between 2',6'-dimethoxyflavone and orthophosphoric acid: a model for flavone-nucleotide interactions. Anticancer Drug Des 8:325-32
Wojtczak, A; Luft, J; Cody, V (1992) Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin. J Biol Chem 267:353-7
Ciszak, E; Cody, V; Luft, J R (1992) Crystal structure determination at 2.3-A resolution of human transthyretin-3',5'-dibromo-2',4,4',6-tetrahydroxyaurone complex. Proc Natl Acad Sci U S A 89:6644-8
Cody, V; Wojtczak, A (1991) Structure of 6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile hydrogen bromide. Acta Crystallogr C 47 ( Pt 8):1742-4
Cody, V; Wojtczak, A (1991) Structure of two polymorphs of 2-methyl-3,4'-bipyridin-6(1H)-one. Acta Crystallogr C 47 ( Pt 4):787-90

Showing the most recent 10 out of 11 publications