Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041077-08
Application #
2141597
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1993-12-24
Project End
1998-11-30
Budget Start
1995-12-15
Budget End
1996-11-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Santiago, J; Sturgill, T W (2001) Identification of the S6 kinase activity stimulated in quiescent brine shrimp embryos upon entry to preemergence development as p70 ribosomal protein S6 kinase: isolation of Artemia franciscana p70S6k cDNA. Biochem Cell Biol 79:141-52
Smith, J A; Poteet-Smith, C E; Lannigan, D A et al. (2000) Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function. J Biol Chem 275:31588-93
Smith, J A; Poteet-Smith, C E; Malarkey, K et al. (1999) Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. J Biol Chem 274:2893-8
Poteet-Smith, C E; Smith, J A; Lannigan, D A et al. (1999) Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family. J Biol Chem 274:22135-8
Malarkey, K; Coker, K J; Sturgill, T W (1998) Ribosomal S6 kinase is activated as an early event in preemergence development of encysted embryos of Artemia salina. Eur J Biochem 251:269-74
Reardon, D B; Dent, P; Wood, S L et al. (1997) Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness. Mol Endocrinol 11:1062-9
Dent, P; Wang, Y; Gu, Y Z et al. (1997) S49 cells endogenously express subtype 2 somatostatin receptors which couple to increase protein tyrosine phosphatase activity in membranes and down-regulate Raf-1 activity in situ. Cell Signal 9:539-49
Rani, C S; Wang, F; Fuior, E et al. (1997) Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. J Biol Chem 272:10777-83
Jelinek, T; Dent, P; Sturgill, T W et al. (1996) Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation. Mol Cell Biol 16:1027-34
Dent, P; Reardon, D B; Wood, S L et al. (1996) Inactivation of raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by Galphai/o subunits. J Biol Chem 271:3119-23

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