Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041487-07
Application #
2141784
Study Section
Pathology A Study Section (PTHA)
Project Start
1990-03-01
Project End
2000-02-29
Budget Start
1996-02-29
Budget End
1997-02-28
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Hinkovska-Galcheva, Vania; Clark, Andrea; VanWay, Susan et al. (2008) Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells. J Lipid Res 49:531-42
Mansfield, Pamela J; Hinkovska-Galcheva, Vania; Borofsky, Michael S et al. (2005) Phagocytic signaling molecules in lipid rafts of COS-1 cells transfected with FcgammaRIIA. Biochem Biophys Res Commun 331:132-8
Mansfield, Pamela J; Carey, Shannon S; Hinkovska-Galcheva, Vania et al. (2004) Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes. Blood 103:2363-8
Mansfield, Pamela J; Hinkovska-Galcheva, Vania; Carey, Shannon S et al. (2002) Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D. Blood 99:1434-41
Mansfield, Pamela J; Hinkovska-Galcheva, Vania; Shayman, James A et al. (2002) Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release. J Lab Clin Med 140:9-16
Cooper, S; Shayman, J A (2001) Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle. Cell Mol Life Sci 58:580-95
Mansfield, P J; Shayman, J A; Boxer, L A (2000) Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase. Blood 95:2407-12
Abe, A; Gregory, S; Lee, L et al. (2000) Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation. J Clin Invest 105:1563-71
Shu, L; Lee, L; Chang, Y et al. (2000) Caveolar structure and protein sorting are maintained in NIH 3T3 cells independent of glycosphingolipid depletion. Arch Biochem Biophys 373:83-90
Raeder, E M; Mansfield, P J; Hinkovska-Galcheva, V et al. (1999) Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation. Blood 93:686-93

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