Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041714-04
Application #
3242555
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1989-08-01
Project End
1994-07-31
Budget Start
1992-08-01
Budget End
1993-07-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Lee, A T; Balasubramanian, K; Schroit, A J (2000) beta(2)-glycoprotein I-dependent alterations in membrane properties. Biochim Biophys Acta 1509:475-84
Dombroski, D; Balasubramanian, K; Schroit, A J (2000) Phosphatidylserine expression on cell surfaces promotes antibody-dependent aggregation and thrombosis in beta2-glycoprotein I-immune mice. J Autoimmun 14:221-9
Diaz, C; Lee, A T; McConkey, D J et al. (1999) Phosphatidylserine externalization during differentiation-triggered apoptosis of erythroleukemic cells. Cell Death Differ 6:218-26
Diaz, C; Balasubramanian, K; Schroit, A J (1998) Synthesis of disulfide-containing phospholipid analogs for the preparation of head group-specific lipid antigens: generation of phosphatidylserine antibodies. Bioconjug Chem 9:250-4
Balasubramanian, K; Killion, J J; Schroit, A J (1998) Estimation of plasma beta-2-glycoprotein levels by competitive ELISA. Thromb Res 92:91-7
Balasubramanian, K; Schroit, A J (1998) Characterization of phosphatidylserine-dependent beta2-glycoprotein I macrophage interactions. Implications for apoptotic cell clearance by phagocytes. J Biol Chem 273:29272-7
Zwaal, R F; Schroit, A J (1997) Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 89:1121-32
Balasubramanian, K; Chandra, J; Schroit, A J (1997) Immune clearance of phosphatidylserine-expressing cells by phagocytes. The role of beta2-glycoprotein I in macrophage recognition. J Biol Chem 272:31113-7
Diaz, C; Schroit, A J (1996) Role of translocases in the generation of phosphatidylserine asymmetry. J Membr Biol 151:1-9
Bruckheimer, E M; Schroit, A J (1996) Membrane phospholipid asymmetry: host response to the externalization of phosphatidylserine. J Leukoc Biol 59:784-8

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