Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041973-08
Application #
2142022
Study Section
Metabolism Study Section (MET)
Project Start
1989-07-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Konopka, Adam R; Esponda, Raul Ruiz; Robinson, Matthew M et al. (2018) Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes. Cell Rep 23:2532
Robinson, Matthew M; Dasari, Surendra; Konopka, Adam R et al. (2017) Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans. Cell Metab 25:581-592
Dutta, Tumpa; Kudva, Yogish C; Persson, Xuan-Mai T et al. (2016) Impact of Long-Term Poor and Good Glycemic Control on Metabolomics Alterations in Type 1 Diabetic People. J Clin Endocrinol Metab 101:1023-33
Johnson, Matthew L; Distelmaier, Klaus; Lanza, Ian R et al. (2016) Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults. Diabetes 65:74-84
Robinson, Matthew M; Dasari, Surendra; Karakelides, Helen et al. (2016) Release of skeletal muscle peptide fragments identifies individual proteins degraded during insulin deprivation in type 1 diabetic humans and mice. Am J Physiol Endocrinol Metab 311:E628-37
Lalia, Antigoni Z; Dasari, Surendra; Johnson, Matthew L et al. (2016) Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans. J Clin Endocrinol Metab 101:626-34
Zabielski, Piotr; Lanza, Ian R; Gopala, Srinivas et al. (2016) Altered Skeletal Muscle Mitochondrial Proteome As the Basis of Disruption of Mitochondrial Function in Diabetic Mice. Diabetes 65:561-73
Konopka, Adam R; Esponda, Raul Ruiz; Robinson, Matthew M et al. (2016) Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes. Cell Rep 15:1394-1400
Manjunatha, Shankarappa; Distelmaier, Klaus; Dasari, Surendra et al. (2016) Functional and proteomic alterations of plasma high density lipoproteins in type 1 diabetes mellitus. Metabolism 65:1421-31
O'Neill, Brian T; Lee, Kevin Y; Klaus, Katherine et al. (2016) Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. J Clin Invest 126:3433-46

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