Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK042509-07
Application #
2142339
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1990-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Michigan State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Smith, W L; Meade, E A; Dewitt, D L (1997) Interaction of PGH synthase isozymes-1 and -2 with nonsteroidal anti-inflammatory drugs. Adv Exp Med Biol 400A:189-96
Smith, W (1997) Molecular biology of prostanoid biosynthetic enzymes and receptors. Adv Exp Med Biol 400B:989-1011
Smith, W L; Garavito, R M; DeWitt, D L (1996) Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271:33157-60
Otto, J C; Smith, W L (1996) Photolabeling of prostaglandin endoperoxide H synthase-1 with 3-trifluoro-3-(m-[125I]iodophenyl)diazirine as a probe of membrane association and the cyclooxygenase active site. J Biol Chem 271:9906-10
Smith, W L; Dewitt, D L (1996) Prostaglandin endoperoxide H synthases-1 and -2. Adv Immunol 62:167-215
Bhattacharyya, D K; Lecomte, M; Rieke, C J et al. (1996) Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1. J Biol Chem 271:2179-84
Kraemer, S A; Arthur, K A; Denison, M S et al. (1996) Regulation of prostaglandin endoperoxide H synthase-2 expression by 2,3,7,8,-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys 330:319-28
Goetzl, E J; An, S; Smith, W L (1995) Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases. FASEB J 9:1051-8
Otto, J C; Smith, W L (1995) Prostaglandin endoperoxide synthases-1 and -2. J Lipid Mediat Cell Signal 12:139-56
Laneuville, O; Breuer, D K; Xu, N et al. (1995) Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid. J Biol Chem 270:19330-6

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