Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK043135-05A1
Application #
2142790
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1991-09-15
Project End
2000-07-31
Budget Start
1996-09-09
Budget End
1997-07-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Ochsner Clinic Foundation
Department
Type
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70121
Zhang, Xuchen; Shan, Peiying; Alam, Jawed et al. (2005) Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. J Biol Chem 280:8714-21
Gonzalez-Michaca, Luis; Farrugia, Gianrico; Croatt, Anthony J et al. (2004) Heme: a determinant of life and death in renal tubular epithelial cells. Am J Physiol Renal Physiol 286:F370-7
Zhang, Xuchen; Shan, Peiying; Alam, Jawed et al. (2003) Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. J Biol Chem 278:22061-70
Alam, Jawed; Killeen, Erin; Gong, Pengfei et al. (2003) Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2. Am J Physiol Renal Physiol 284:F743-52
Zhang, Xuchen; Shan, Peiying; Otterbein, Leo E et al. (2003) Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem 278:1248-58
Kanakiriya, Sharan K R; Croatt, Anthony J; Haggard, Jill J et al. (2003) Heme: a novel inducer of MCP-1 through HO-dependent and HO-independent mechanisms. Am J Physiol Renal Physiol 284:F546-54
Zhang, Xuchen; Bedard, Eric L; Potter, Richard et al. (2002) Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. Am J Physiol Lung Cell Mol Physiol 283:L815-29
Gong, Pengfei; Stewart, Daniel; Hu, Bin et al. (2002) Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch Biochem Biophys 405:265-74
Gong, Pengfei; Stewart, Daniel; Hu, Bin et al. (2002) Activation of the mouse heme oxygenase-1 gene by 15-deoxy-Delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2. Antioxid Redox Signal 4:249-57
Lu, Huasheng; Hunt, Diana Margaret; Ganti, Ramapriya et al. (2002) Metallothionein protects retinal pigment epithelial cells against apoptosis and oxidative stress. Exp Eye Res 74:83-92

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