Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK043279-02
Application #
3244641
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1992-05-01
Project End
1995-04-30
Budget Start
1992-09-01
Budget End
1993-04-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Gottlieb, P A; Eisenbarth, G S (1998) Diagnosis and treatment of pre-insulin dependent diabetes. Annu Rev Med 49:391-405
Kawasaki, E; Yu, L; Rewers, M J et al. (1998) Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes. Diabetes 47:733-42
Eisenbarth, G S; Gianani, R; Yu, L et al. (1998) Dual-parameter model for prediction of type I diabetes mellitus. Proc Assoc Am Physicians 110:126-35
Kawasaki, E; Yu, L; Gianani, R et al. (1997) Evaluation of islet cell antigen (ICA) 512/IA-2 autoantibody radioassays using overlapping ICA512/IA-2 constructs. J Clin Endocrinol Metab 82:375-80
Simone, E; Eisenbarth, G S (1996) Chronic autoimmunity of type I diabetes. Horm Metab Res 28:332-6
Kawasaki, E; Hutton, J C; Eisenbarth, G S (1996) Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes. Biochem Biophys Res Commun 227:440-7
Verge, C F; Gianani, R; Kawasaki, E et al. (1996) Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-33
Yu, L; Rewers, M; Gianani, R et al. (1996) Antiislet autoantibodies usually develop sequentially rather than simultaneously. J Clin Endocrinol Metab 81:4264-7
Verge, C F; Gianani, R; Kawasaki, E et al. (1996) Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes. J Autoimmun 9:379-83
Kawasaki, E; Eisenbarth, G S; Wasmeier, C et al. (1996) Autoantibodies to protein tyrosine phosphatase-like proteins in type I diabetes. Overlapping specificities to phogrin and ICA512/IA-2. Diabetes 45:1344-9

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