Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043377-05
Application #
2142972
Study Section
Physiology Study Section (PHY)
Project Start
1991-08-01
Project End
1997-07-31
Budget Start
1995-08-01
Budget End
1997-07-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Physiology
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Stroffekova, K; Kupert, E Y; Malinowska, D H et al. (1998) Identification of the pH sensor and activation by chemical modification of the ClC-2G Cl- channel. Am J Physiol 275:C1113-23
Sherry, A M; Stroffekova, K; Knapp, L M et al. (1997) Characterization of the human pH- and PKA-activated ClC-2G(2 alpha) Cl- channel. Am J Physiol 273:C384-93
Huang, P; Stroffekova, K; Cuppoletti, J et al. (1996) Functional expression of the cystic fibrosis transmembrane conductance regulator in yeast. Biochim Biophys Acta 1281:80-90
El-Etri, M; Cuppoletti, J (1996) Metalloporphyrin chloride ionophores: induction of increased anion permeability in lung epithelial cells. Am J Physiol 270:L386-92
Malinowska, D H; Kupert, E Y; Bahinski, A et al. (1995) Cloning, functional expression, and characterization of a PKA-activated gastric Cl- channel. Am J Physiol 268:C191-200
Sherry, A M; Cuppoletti, J; Malinowska, D H (1994) Differential acidic pH sensitivity of delta F508 CFTR Cl- channel activity in lipid bilayers. Am J Physiol 266:C870-5
Cuppoletti, J; Huang, P; Kaetzel, M A et al. (1993) Stimulus-associated protein in gastric parietal cell detected using antimelittin antibody. Am J Physiol 264:G637-44
Cuppoletti, J; Baker, A M; Malinowska, D H (1993) Cl- channels of the gastric parietal cell that are active at low pH. Am J Physiol 264:C1609-18
Cuppoletti, J; Chernyak, B V; Huang, P et al. (1992) Structure-function relationships in the interaction of amphipathic helical polypeptides with the gastric H/K ATPase. Ann N Y Acad Sci 671:443-5
Cuppoletti, J; Malinowska, D H (1992) Interaction of polypeptides with the gastric (H+ + K+)ATPase: melittin, synthetic analogs, and a potential intracellular regulatory protein. Mol Cell Biochem 114:57-63