Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043613-04
Application #
2143101
Study Section
Pathology A Study Section (PTHA)
Project Start
1993-03-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215
Hattori, M; Yamato, E; Itoh, N et al. (1999) Cutting edge: homologous recombination of the MHC class I K region defines new MHC-linked diabetogenic susceptibility gene(s) in nonobese diabetic mice. J Immunol 163:1721-4
Liu, Z H; Striker, L J; Hattori, M et al. (1996) Localization of glutamic acid decarboxylase in the kidneys of nonobese diabetic mice. Nephron 72:662-6
Davar, G; Waikar, S; Eisenberg, E et al. (1995) Behavioral evidence of thermal hyperalgesia in non-obese diabetic mice with and without insulin-dependent diabetes. Neurosci Lett 190:171-4
Skarstein, K; Wahren, M; Zaura, E et al. (1995) Characterization of T cell receptor repertoire and anti-Ro/SSA autoantibodies in relation to sialadenitis of NOD mice. Autoimmunity 22:9-16
Yang, C W; Hattori, M; Vlassara, H et al. (1995) Overexpression of transforming growth factor-beta 1 mRNA is associated with up-regulation of glomerular tenascin and laminin gene expression in nonobese diabetic mice. J Am Soc Nephrol 5:1610-7
Burkly, L C; Jakubowski, A; Hattori, M (1994) Protection against adoptive transfer of autoimmune diabetes mediated through very late antigen-4 integrin. Diabetes 43:529-34
Horio, F; Fukuda, M; Katoh, H et al. (1994) Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells. Diabetologia 37:22-31
Elliot, S J; Striker, L J; Hattori, M et al. (1993) Mesangial cells from diabetic NOD mice constitutively secrete increased amounts of insulin-like growth factor-I. Endocrinology 133:1783-8