Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043709-05
Application #
2143188
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1990-09-01
Project End
1996-03-31
Budget Start
1994-08-01
Budget End
1996-03-31
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Genetics
Type
Schools of Public Health
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Takiyama, N; Mohney, T; Swaney, W et al. (1998) Comparison of methods for retroviral mediated transfer of glucocerebrosidase gene to CD34+ hematopoietic progenitor cells. Eur J Haematol 61:1-6
Liu, C; Bahnson, A B; Dunigan, J T et al. (1998) Long-term expression and secretion of human glucocerebrosidase by primary murine and human myoblasts and differentiated myotubes. J Mol Med 76:773-81
Liu, C; Dunigan, J T; Watkins, S C et al. (1998) Long-term expression, systemic delivery, and macrophage uptake of recombinant human glucocerebrosidase in mice transplanted with genetically modified primary myoblasts. Hum Gene Ther 9:2375-84
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Mannion-Henderson, J; Kemp, A; Mohney, T et al. (1995) Efficient retroviral mediated transfer of the glucocerebrosidase gene in CD34+ enriched umbilical cord blood human hematopoietic progenitors. Exp Hematol 23:1628-32
Barranger, J A; Tomich, J; Weiler, S et al. (1995) Molecular biology of glucocerebrosidase and the treatment of Gaucher disease. Cytokines Mol Ther 1:149-63
Weiler, S; Kishimoto, Y; O'Brien, J S et al. (1995) Identification of the binding and activating sites of the sphingolipid activator protein, saposin C, with glucocerebrosidase. Protein Sci 4:756-64
O'Brien, J S; Carson, G S; Seo, H C et al. (1995) Identification of the neurotrophic factor sequence of prosaposin. FASEB J 9:681-5
Ohashi, T; Matalon, R; Barranger, J A et al. (1995) Overexpression of arylsulfatase A gene in fibroblasts from metachromatic leukodystrophy patients does not induce a new phenotype. Gene Ther 2:363-8
Nimgaonkar, M; Mierski, J; Beeler, M et al. (1995) Cytokine mobilization of peripheral blood stem cells in patients with Gaucher disease with a view to gene therapy. Exp Hematol 23:1633-41

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