Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043719-04
Application #
2143203
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1992-05-15
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Broudy, V C; Lin, N L; Sabath, D F (2001) The fifth immunoglobulin-like domain of the Kit receptor is required for proteolytic cleavage from the cell surface. Cytokine 15:188-95
Dahlen, D D; Lin, N L; Liu, Y C et al. (2001) Soluble Kit receptor blocks stem cell factor bioactivity in vitro. Leuk Res 25:413-21
Broudy, V C; Lin, N L; Liles, W C et al. (1999) Signaling via Src family kinases is required for normal internalization of the receptor c-Kit. Blood 94:1979-86
Broudy, V C; Lin, N L; Buhring, H J et al. (1998) Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer. Blood 91:898-906
Kaushansky, K (1997) Thrombopoietin: platelets on demand? Ann Intern Med 126:731-3
Broudy, V C; Lin, N L; Kaushansky, K (1995) Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85:1719-26
Kaushansky, K; Broudy, V C; Lin, N et al. (1995) Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci U S A 92:3234-8
Drachman, J G; Griffin, J D; Kaushansky, K (1995) The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J Biol Chem 270:4979-82
Kaushansky, K (1994) The mpl ligand: molecular and cellular biology of the critical regulator of megakaryocyte development. Stem Cells 12 Suppl 1:91-6;discussion 96-7
Kaushansky, K; Shoemaker, S G; O'Rork, C A et al. (1994) Coordinate regulation of multiple human lymphokine genes by Oct-1 and potentially novel 45 and 43 kDa polypeptides. J Immunol 152:1812-20

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