Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK043901-04
Application #
2143401
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1992-09-01
Project End
1997-01-06
Budget Start
1996-04-01
Budget End
1997-01-06
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Surgery
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Brouha, P C; Ildstad, S T (2001) Mixed allogeneic chimerism. Past, present, and prospects for the future. Transplantation 72:S36-42
Neipp, M; Gammie, J S; Exner, B G et al. (1999) A partial conditioning approach to achieve mixed chimerism in the rat: depletion of host natural killer cells significantly reduces the amount of total body irradiation required for engraftment. Transplantation 68:369-78
Neipp, M; Exner, B G; Maru, D et al. (1999) T-cell depletion of allogeneic bone marrow using anti-alphabetaTCR monoclonal antibody: prevention of graft-versus-host disease without affecting engraftment potential in rats. Exp Hematol 27:860-7
Exner, B G; Acholonu, I N; Bergheim, M et al. (1999) Mixed allogeneic chimerism to induce tolerance to solid organ and cellular grafts. Acta Haematol 101:78-81
Exner, B G; Domenick, M A; Bergheim, M et al. (1999) Clinical applications of mixed chimerism. Ann N Y Acad Sci 872:377-85;discussion 385-6
Neipp, M; Exner, B G; Ildstad, S T (1998) A nonlethal conditioning approach to achieve engraftment of xenogeneic rat bone marrow in mice and to induce donor-specific tolerance. Transplantation 66:969-75
Colson, Y L; Li, H; Boggs, S S et al. (1996) Durable mixed allogeneic chimerism and tolerance by a nonlethal radiation-based cytoreductive approach. J Immunol 157:2820-9
Colson, Y L; Lange, J; Fowler, K et al. (1996) Mechanism for cotolerance in nonlethally conditioned mixed chimeras: negative selection of the Vbeta T-cell receptor repertoire by both host and donor bone marrow-derived cells. Blood 88:4601-10
Wren, S M; Wang, S C; Thai, N L et al. (1993) Evidence for early Th 2 T cell predominance in xenoreactivity. Transplantation 56:905-11
Kaufman, C L; Chambers, W H; Ildstad, S T (1993) Coexpression of NKR-P1 and alpha beta-TCR on lymphoid cells in fully xenogeneic (rat-->mouse) chimeras and syngeneically reconstituted (A-->A) rats. J Immunol 151:6002-11

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