Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK043988-05
Application #
2143444
Study Section
Pathology A Study Section (PTHA)
Project Start
1991-05-15
Project End
2001-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Block, Karen; Gorin, Yves; Abboud, Hanna E (2009) Subcellular localization of Nox4 and regulation in diabetes. Proc Natl Acad Sci U S A 106:14385-90
Block, Karen; Ricono, Jill M; Lee, Duck-Yoon et al. (2006) Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKB. Antioxid Redox Signal 8:1497-508
Kim, Nam-Ho; Rincon-Choles, Hernan; Bhandari, Basant et al. (2006) Redox dependence of glomerular epithelial cell hypertrophy in response to glucose. Am J Physiol Renal Physiol 290:F741-51
Gorin, Yves; Block, Karen; Hernandez, James et al. (2005) Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem 280:39616-26
Gorin, Yves; Ricono, Jill M; Wagner, Brent et al. (2004) Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Biochem J 381:231-9
Ghosh Choudhury, Goutam; Abboud, Hanna E (2004) Tyrosine phosphorylation-dependent PI 3 kinase/Akt signal transduction regulates TGFbeta-induced fibronectin expression in mesangial cells. Cell Signal 16:31-41
Gorin, Yves; Ricono, Jill M; Kim, Nam-Ho et al. (2003) Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Am J Physiol Renal Physiol 285:F219-29
Simon, Matthias; Feliers, Denis; Arar, Mazen et al. (2002) Cloning of the 5'-flanking region of the murine bone morphogenetic protein-7 gene. Mol Cell Biochem 233:31-7
Gorin, Y; Kim, N H; Feliers, D et al. (2001) Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox-dependent pathway and independent of phosphoinositide 3-kinase. FASEB J 15:1909-20
Choudhury, G G; Grandaliano, G; Jin, D C et al. (2000) Activation of PLC and PI 3 kinase by PDGF receptor alpha is not sufficient for mitogenesis and migration in mesangial cells. Kidney Int 57:908-17

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