Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK044367-03
Application #
2143756
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1994-03-01
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Gregory, Stephen H; Cousens, Leslie P; van Rooijen, Nico et al. (2002) Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver. J Immunol 168:308-15
Cousens, L P; Wing, E J (2000) Innate defenses in the liver during Listeria infection. Immunol Rev 174:150-9
Gregory, S H; Liu, C C (2000) CD8+ T-cell-mediated response to Listeria monocytogenes taken up in the liver and replicating within hepatocytes. Immunol Rev 174:112-22
Gregory, S H; Wing, E J (1998) Neutrophil-Kupffer-cell interaction in host defenses to systemic infections. Immunol Today 19:507-10
Jensen, E R; Glass, A A; Clark, W R et al. (1998) Fas (CD95)-dependent cell-mediated immunity to Listeria monocytogenes. Infect Immun 66:4143-50
Gregory, S H; Wing, E J; Danowski, K L et al. (1998) IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections. J Immunol 160:6056-61
Jiang, X; Gregory, S H; Wing, E J (1997) Immune CD8+ T lymphocytes lyse Listeria monocytogenes-infected hepatocytes by a classical MHC class I-restricted mechanism. J Immunol 158:287-93
Gregory, S H; Sagnimeni, A J; Wing, E J (1997) Internalin B promotes the replication of Listeria monocytogenes in mouse hepatocytes. Infect Immun 65:5137-41
Gregory, S H; Sagnimeni, A J; Wing, E J (1996) Expression of the inlAB operon by Listeria monocytogenes is not required for entry into hepatic cells in vivo. Infect Immun 64:3983-6
Gregory, S H; Sagnimeni, A J; Wing, E J (1996) Bacteria in the bloodstream are trapped in the liver and killed by immigrating neutrophils. J Immunol 157:2514-20

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