Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK044441-03
Application #
2143792
Study Section
General Medicine B Study Section (GMB)
Project Start
1994-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Derfoul, A; Robertson, N M; Hall, D J et al. (2000) The N-terminal domain of the mineralocorticoid receptor modulates both mineralocorticoid receptor- and glucocorticoid receptor-mediated transactivation from Na/K ATPase beta1 target gene promoter. Endocrine 13:287-95
Bostanjoglo, M; Reeves, W B; Reilly, R F et al. (1998) 11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules. J Am Soc Nephrol 9:1347-58
Derfoul, A; Robertson, N M; Lingrel, J B et al. (1998) Regulation of the human Na/K-ATPase beta1 gene promoter by mineralocorticoid and glucocorticoid receptors. J Biol Chem 273:20702-11
Bruner, K L; Derfoul, A; Robertson, N M et al. (1997) The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. Recept Signal Transduct 7:85-98
Robertson, N M; Zangrilli, J; Fernandes-Alnemri, T et al. (1997) Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death. Cancer Res 57:43-7
Schumacher, R J; Hansen, W J; Freeman, B C et al. (1996) Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation. Biochemistry 35:14889-98
Bodine, P V; Litwack, G (1995) Purification of the glucocorticoid receptor-mineralocorticoid receptor modulator-2 from rabbit liver. Receptor 5:133-43
Robertson, N M; Bodine, P V; Hsu, T C et al. (1995) Modulator inhibits nuclear translocation of the glucocorticoid receptor and inhibits glucocorticoid-induced apoptosis in the human leukemic cell line CEM C-7. Cancer Res 55:548-56