Immunobiology of the Thyrotropin Receptor

Prabhakar, Bellur S.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 1R01DK044972-01A5
• Application #: 2144208
• Study Section: Endocrinology Study Section (END)
• Project Start: 1996-06-01
• Project End: 2000-05-31
• Budget Start: 1996-06-01
• Budget End: 1997-05-31
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: University of Texas Medical Br Galveston
• Department: Microbiology/Immun/Virology
• Type: Schools of Medicine
• DUNS #: 041367053
• City: Galveston
• State: TX
• Country: United States
• Zip Code: 77555

Publications

Singh, Surya P; McDonald, David; Hope, Thomas J et al. (2004) Upon thyrotropin binding the thyrotropin receptor is internalized and localized to endosome. Endocrinology 145:1003-10

Gangi, Eryn; Kapatral, Vinayak; El-Azami El-Idrissi, Mohammed et al. (2004) Characterization of a recombinant Yersinia enterocolitica lipoprotein; implications for its role in autoimmune response against thyrotropin receptor. Autoimmunity 37:515-20

Dogan, Rukiye-Nazan E; Vasu, Chenthamarakshan; Holterman, Mark J et al. (2003) Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease. J Immunol 170:2195-204

Vasu, Chenthamarakshan; Holterman, Mark J; Prabhakar, Bellur S (2003) Modulation of dendritic cell function and cytokine production to prevent thyroid autoimmunity. Autoimmunity 36:389-96

Prasad, Kanteti V; Prabhakar, Bellur S (2003) Apoptosis and autoimmune disorders. Autoimmunity 36:323-30

Cundiff, J G; Kaithamana, S; Seetharamaiah, G S et al. (2001) Studies using recombinant fragments of human TSH receptor reveal apparent diversity in the binding specificities of antibodies that block TSH binding to its receptor or stimulate thyroid hormone production. J Clin Endocrinol Metab 86:4254-60

Melnikov, A; Zaborina, O; Dhiman, N et al. (2000) Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells. Mol Microbiol 36:1481-93

Fan, J L; Peterson, J W; Prabhakar, B S (2000) Adjuvant effects of cholera toxin b subunit on immune response to recombinant thyrotropin receptor in mice. J Autoimmun 14:43-52

Seetharamaiah, G S; Kaithamana, S; Desai, R K et al. (1999) Regulation of thyrotropin receptor protein expression in insect cells. J Mol Endocrinol 23:315-23

Patibandla, S A; Fan, J L; Prabhakar, B S et al. (1999) Comparison of immune responses to extracellular domains of mouse and human thyrotropin receptor. J Autoimmun 13:205-13