This is a competitive renewal of a project aimed at understanding regional differences in fatty acid metabolism. It is clear that there are regional differences in fat distribution, that ultimately must be due to regional differences in either lipolysis or fat uptake. However, which processes differ is not known. The P.I. has used the stable isotope tracers, delivered in meals, and combined with adipose biopsies to study fatty acid uptake and disposal. Using tracers, fat can be oxidized, stored in subcutaneous fat or unaccounted for. It is assumed that this fat is stored in visceral adipose tissue. The P.I. found that upper body subcutaneous fat took up more meal fatty acids than lower body subcutaneous fat, but that men and women did not differ in this process. It is thought by the P.I. that the isocaloric feeding involved in these studies may have masked gender differences and that perturbations in energy balance may also be required. Thus the P.I. proposes to study the effects of amount of dietary fat on the meal fatty acid disposal in non-obese men and women. The P.I. will also recruit patients scheduled for elective laparoscopy in order to determine if the unaccounted for tracer ends up in visceral fat. The hypothesis to be tested is that regional differences in body fat gain in response to overfeeding will be due to differences in regional differences in fatty acid uptake.
| Chung, Jin Ook; Koutsari, Christina; Blachnio-Zablieska, Agnieszka Urszula et al. (2018) Effects of meal ingestion on intramyocellular ceramide concentrations and fractional de novo synthesis in humans. Am J Physiol Endocrinol Metab 314:E105-E114 |
| Lu, Jin; Allred, Carolyn C; Jensen, Michael D (2018) Human adipose tissue protein analyses using capillary western blot technology. Nutr Diabetes 8:26 |
| Bray, George A; Heisel, William E; Afshin, Ashkan et al. (2018) The Science of Obesity Management: An Endocrine Society Scientific Statement. Endocr Rev 39:79-132 |
| Espinosa De Ycaza, A E; Donegan, D; Jensen, M D (2018) Long-term metabolic risk for the metabolically healthy overweight/obese phenotype. Int J Obes (Lond) 42:302-309 |
| Morgan-Bathke, Maria; Harteneck, Debra; Jaeger, Philippa et al. (2017) Comparison of Methods for Analyzing Human Adipose Tissue Macrophage Content. Obesity (Silver Spring) 25:2100-2107 |
| Santosa, Sylvia; Bush, Nikki C; Jensen, Michael D (2017) Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage. J Clin Endocrinol Metab 102:3056-3064 |
| Chung, Jin Ook; Koutsari, Christina; Blachnio-Zabielska, Agnieszka U et al. (2017) Intramyocellular Ceramides: Subcellular Concentrations and Fractional De Novo Synthesis in Postabsorptive Humans. Diabetes 66:2082-2091 |
| Lu, Jin; Varghese, Ron T; Zhou, Lianzhen et al. (2017) Glucose tolerance and free fatty acid metabolism in adults with variations in TCF7L2 rs7903146. Metabolism 68:55-63 |
| Anthanont, P; Ramos, P; Jensen, M D et al. (2017) Family history of type 2 diabetes, abdominal adipocyte size and markers of the metabolic syndrome. Int J Obes (Lond) 41:1621-1626 |
| Søndergaard, Esben; Espinosa De Ycaza, Ana Elena; Morgan-Bathke, Maria et al. (2017) How to Measure Adipose Tissue Insulin Sensitivity. J Clin Endocrinol Metab 102:1193-1199 |
Showing the most recent 10 out of 118 publications
