Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK045371-04A1
Application #
2144600
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1992-09-30
Project End
2001-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Surgery
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Fassett, John T; Tobolt, Diane; Nelsen, Christopher J et al. (2003) The role of collagen structure in mitogen stimulation of ERK, cyclin D1 expression, and G1-S progression in rat hepatocytes. J Biol Chem 278:31691-700
Tzanakakis, E S; Waxman, D J; Hansen, L K et al. (2002) Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer. Cell Biol Toxicol 18:13-27
Tzanakakis, E S; Hansen, L K; Hu, W S (2001) The role of actin filaments and microtubules in hepatocyte spheroid self-assembly. Cell Motil Cytoskeleton 48:175-89
Tzanakakis, E S; Hsiao, C C; Matsushita, T et al. (2001) Probing enhanced cytochrome P450 2B1/2 activity in rat hepatocyte spheroids through confocal laser scanning microscopy. Cell Transplant 10:329-42
Hosagrahara, V P; Hansen, L K; Remmel, R P (1999) Induction of the metabolism of midazolam by rifampin in cultured porcine hepatocytes: preliminary evidence for CYP3A isoforms in pigs. Drug Metab Dispos 27:1512-8
Peshwa, M V; Wu, F J; Sharp, H L et al. (1996) Mechanistics of formation and ultrastructural evaluation of hepatocyte spheroids. In Vitro Cell Dev Biol Anim 32:197-203
Hu, M Y; Cipolle, M; Sielaff, T et al. (1995) Effects of hepatocyte growth factor on viability and biotransformation functions of hepatocytes in gel entrapped and monolayer culture. Crit Care Med 23:1237-42
Hu, M Y; Sielaff, T D; Cerra, F B (1994) Enhancement of cytochrome P450 function of collagen-entrapped hepatocytes by the addition of liver extracellular matrix components. Transplant Proc 26:3293
Cipolle, M D; Pasquale, M D; Shearer, J et al. (1994) Blunt injury augments interleukin-6 but not tumor necrosis factor in isolated, perfused rat hindlimbs. J Trauma 37:91-8;discussion 98-9
Nyberg, S L; Remmel, R P; Mann, H J et al. (1994) Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver. Ann Surg 220:59-67

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