Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK045453-04
Application #
2144703
Study Section
Metabolism Study Section (MET)
Project Start
1992-09-30
Project End
1997-09-29
Budget Start
1995-09-30
Budget End
1997-09-29
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Yorek, M A; Dunlap, J A; Lowe Jr, W L (2000) Wortmannin and LY294002 inhibit myo-inositol accumulation by cultured bovine aorta endothelial cells and murine 3T3-L1 adipocytes. Biochim Biophys Acta 1497:328-40
Yorek, M A; Dunlap, J A; Liu, W et al. (2000) Normalization of hyperosmotic-induced inositol uptake by renal and endothelial cells is regulated by NF-kappaB. Am J Physiol Cell Physiol 278:C1011-8
Yorek, M A; Dunlap, J A; Lowe Jr, W L (1999) Osmotic regulation of the Na+/myo-inositol cotransporter and postinduction normalization. Kidney Int 55:215-24
Yorek, M A; Dunlap, J A; Thomas, M J et al. (1998) Effect of TNF-alpha on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells. Am J Physiol 274:C58-71
Yorek, M A; Wiese, T J; Davidson, E P et al. (1996) Reduced Na+/K+ adenosine triphosphatase activity and motor nerve conduction velocity in L-fucose-fed rats is reversible after dietary normalization. Metabolism 45:229-34
Wiese, T J; Dunlap, J A; Conner, C E et al. (1996) Osmotic regulation of Na-myo-inositol cotransporter mRNA level and activity in endothelial and neural cells. Am J Physiol 270:C990-7
Wiese, T J; Matsushita, K; Lowe Jr, W L et al. (1996) Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats. Kidney Int 50:1202-11
Yorek, M A; Conner, C E; Spanheimer, R G (1995) L-fucose reduces collagen and noncollagen protein production in cultured cerebral microvessel endothelial cells. J Cell Physiol 165:658-66
Wachtel, R E; Kraske, S A; Yorek, M A (1995) Sodium channels in cultured neuroblastoma cells grown in high glucose or L-fucose. J Membr Biol 145:187-92
Yorek, M A; Dunlap, J A; Stefani, M R et al. (1994) Reduced Na+/K+ ATPase transport activity, resting membrane potential, and bradykinin-stimulated phosphatidylinositol synthesis by polyol accumulation in cultured neuroblastoma cells. Neurochem Res 19:321-30

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