Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046190-23
Application #
2145377
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1982-08-01
Project End
1997-07-31
Budget Start
1996-08-28
Budget End
1997-07-31
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Surgery
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Gasser, Martin; Waaga-Gasser, Ana Maria; Grimm, Michael W et al. (2005) Selectin blockade plus therapy with low-dose sirolimus and cyclosporin a prevent brain death-induced renal allograft dysfunction. Am J Transplant 5:662-70
Pratschke, Johann; Paz, Dustin; Wilhelm, Markus J et al. (2004) Donor hypertension increases graft immunogenicity and intensifies chronic changes in long-surviving renal allografts. Transplantation 77:43-8
Gasser, Martin; Waaga, Ana Maria; Kist-Van Holthe, Joana E et al. (2002) Normalization of brain death-induced injury to rat renal allografts by recombinant soluble P-selectin glycoprotein ligand. J Am Soc Nephrol 13:1937-45
Laskowski, Igor A; Pratschke, Johann; Wilhelm, Markus J et al. (2002) Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats. J Am Soc Nephrol 13:519-27
Wilhelm, M J; Pratschke, J; Beato, F et al. (2002) Activation of proinflammatory mediators in heart transplants from brain-dead donors: evidence from a model of chronic rat cardiac allograft rejection. Transplant Proc 34:2359-60
Laskowski, Igor A; Pratschke, Johann; Wilhelm, Marcus M et al. (2002) Early and late injury to renal transplants from non-heart-beating donors. Transplantation 73:1468-73
Tilney, N L; Paz, D; Ames, J et al. (2001) Ischemia-reperfusion injury. Transplant Proc 33:843-4
Laskowski, I A; Pratschke, J; Wilhelm, M J et al. (2001) Prolongation of survival and preservation of allograft structure and function by a signaling CD28 mAB in a rat model of chronic kidney rejection. Transplant Proc 33:567-8
Laskowski, I A; Hancock, W W; Pratchke, J et al. (2001) Accelerated graft dysfunction in renal isografts from non-heart-beating donors. Transplant Proc 33:909-10
Pratschke, J; Wilhelm, M J; Laskowski, I et al. (2001) Influence of donor brain death on chronic rejection of renal transplants in rats. J Am Soc Nephrol 12:2474-81

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