Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046422-04
Application #
2145633
Study Section
General Medicine B Study Section (GMB)
Project Start
1993-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Kifor, Olga; Kifor, Imre; Brown, Edward M (2002) Signal transduction in the parathyroid. Curr Opin Nephrol Hypertens 11:397-402
Brown, E M; MacLeod, R J (2001) Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81:239-297
Carling, T; Szabo, E; Bai, M et al. (2000) Familial hypercalcemia and hypercalciuria caused by a novel mutation in the cytoplasmic tail of the calcium receptor. J Clin Endocrinol Metab 85:2042-7
Brown, E M (2000) G protein-coupled, extracellular Ca2+ (Ca2+(o))-sensing receptor enables Ca2+(o) to function as a versatile extracellular first messenger. Cell Biochem Biophys 33:63-95
Brown, E M; Vassilev, P M; Quinn, S et al. (1999) G-protein-coupled, extracellular Ca(2+)-sensing receptor: a versatile regulator of diverse cellular functions. Vitam Horm 55:1-71
Brown, E M; Pollak, M; Hebert, S C (1998) The extracellular calcium-sensing receptor: its role in health and disease. Annu Rev Med 49:15-29
Watanabe, T; Bai, M; Lane, C R et al. (1998) Familial hypoparathyroidism: identification of a novel gain of function mutation in transmembrane domain 5 of the calcium-sensing receptor. J Clin Endocrinol Metab 83:2497-502
Kovacs, C S; Ho-Pao, C L; Hunzelman, J L et al. (1998) Regulation of murine fetal-placental calcium metabolism by the calcium-sensing receptor. J Clin Invest 101:2812-20
Brown, E M (1997) Mutations in the calcium-sensing receptor and their clinical implications. Horm Res 48:199-208
Bai, M; Pearce, S H; Kifor, O et al. (1997) In vivo and in vitro characterization of neonatal hyperparathyroidism resulting from a de novo, heterozygous mutation in the Ca2+-sensing receptor gene: normal maternal calcium homeostasis as a cause of secondary hyperparathyroidism in familial benign hyp J Clin Invest 99:88-96

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