Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046984-11
Application #
6691098
Study Section
Special Emphasis Panel (ZRG1-PC (02))
Program Officer
Haft, Carol R
Project Start
1994-06-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
11
Fiscal Year
2004
Total Cost
$307,380
Indirect Cost
Name
Johns Hopkins University
Department
Biochemistry
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Wang, Min; Cheng, Dongmei; Peng, Junmin et al. (2006) Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase. EMBO J 25:1710-9
Flick, Karin; Raasi, Shahri; Zhang, Hongwei et al. (2006) A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome. Nat Cell Biol 8:509-15
Wang, Min; Pickart, Cecile M (2005) Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis. EMBO J 24:4324-33
Pickart, Cecile M (2004) Back to the future with ubiquitin. Cell 116:181-90
Raasi, Shahri; Orlov, Irina; Fleming, Karen G et al. (2004) Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A. J Mol Biol 341:1367-79
Pickart, Cecile M; Eddins, Michael J (2004) Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta 1695:55-72
Zhang, Mingsheng; Pickart, Cecile M; Coffino, Philip (2003) Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. EMBO J 22:1488-96
You, Jianxin; Wang, Min; Aoki, Tsutomu et al. (2003) Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. J Biol Chem 278:23369-75
Raasi, Shahri; Pickart, Cecile M (2003) Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains. J Biol Chem 278:8951-9
Varadan, Ranjani; Walker, Olivier; Pickart, Cecile et al. (2002) Structural properties of polyubiquitin chains in solution. J Mol Biol 324:637-47

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