Functions of Pth/Pthrp Receptor, Pthrp and Pth in Vivo

Kronenberg, Henry M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK047038-03
• Application #: 2146354
• Study Section: Orthopedics and Musculoskeletal Study Section (ORTH)
• Project Start: 1994-06-01
• Project End: 1999-05-31
• Budget Start: 1996-06-01
• Budget End: 1997-05-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Massachusetts General Hospital
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02199

Publications

Rubin, Lewis P; Kovacs, Christopher S; De Paepe, Monique E et al. (2004) Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Dev Dyn 230:278-89

Rossi, Ferdinand; MacLean, Helen E; Yuan, Wei et al. (2002) p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development. Dev Biol 247:271-85

Kovacs, C S; Manley, N R; Moseley, J M et al. (2001) Fetal parathyroids are not required to maintain placental calcium transport. J Clin Invest 107:1007-15

Huang, W; Chung, U I; Kronenberg, H M et al. (2001) The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc Natl Acad Sci U S A 98:160-5

Lanske, B; Amling, M; Neff, L et al. (1999) Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development. J Clin Invest 104:399-407

Divieti, P; Lanske, B; Kronenberg, H M et al. (1998) Conditionally immortalized murine osteoblasts lacking the type 1 PTH/PTHrP receptor. J Bone Miner Res 13:1835-45

Lanske, B; Kronenberg, H M (1998) Parathyroid hormone-related peptide (PTHrP) and parathyroid hormone (PTH)/PTHrP receptor. Crit Rev Eukaryot Gene Expr 8:297-320

Lanske, B; Divieti, P; Kovacs, C S et al. (1998) The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology 139:5194-204

Kronenberg, H M; Lanske, B; Kovacs, C S et al. (1998) Functional analysis of the PTH/PTHrP network of ligands and receptors. Recent Prog Horm Res 53:283-301;discussion 301-3

Chung, U I; Lanske, B; Lee, K et al. (1998) The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci U S A 95:13030-5