Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047199-03
Application #
2146544
Study Section
General Medicine B Study Section (GMB)
Project Start
1994-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Hope College
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Holland
State
MI
Country
United States
Zip Code
49422
Burnatowska-Hledin, Maria A; Barney, Christopher C (2014) New insights into the mechanism for VACM-1/cul5 expression in vascular tissue in vivo. Int Rev Cell Mol Biol 313:79-101
Le, Isabelle P; Schultz, Sarah; Andresen, Bradley T et al. (2012) Aquaporin-2 levels in vitro and in vivo are regulated by VACM-1, a cul 5 gene. Cell Physiol Biochem 30:1148-58
Johnson, Alyssa E; Le, Isabelle P; Andresen, Bradley T et al. (2012) VACM-1/cul5 expression in vascular tissue in vivo is induced by water deprivation and its expression in vitro regulates aquaporin-1 concentrations. Cell Tissue Res 349:527-39
Bradley, Shirley E; Johnson, Alyssa E; Le, Isabelle P et al. (2010) Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect. J Biol Chem 285:4883-95
Iqbal, Jahangir; Dai, Kezhi; Seimon, Tracie et al. (2008) IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab 7:445-55
Buchwalter, A; Van Dort, C; Schultz, S et al. (2008) Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype. Microvasc Res 75:155-68
Sartor, Ashleigh; Kossoris, J B; Wilcox, R et al. (2006) Truncated form of VACM-1/cul-5 with an extended 3' untranslated region stimulates cell growth via a MAPK-dependent pathway. Biochem Biophys Res Commun 343:1086-93
Burnatowska-Hledin, Maria A; Kossoris, Jennifer B; Van Dort, Christa J et al. (2004) T47D breast cancer cell growth is inhibited by expression of VACM-1, a cul-5 gene. Biochem Biophys Res Commun 319:817-25
Van Dort, C; Zhao, P; Parmelee, K et al. (2003) VACM-1, a cul-5 gene, inhibits cellular growth by a mechanism that involves MAPK and p53 signaling pathways. Am J Physiol Cell Physiol 285:C1386-96
Burnatowska-Hledin; Zeneberg, A; Roulo, A et al. (2001) Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle. Endothelium 8:49-63

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