Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047416-07
Application #
6524203
Study Section
Special Emphasis Panel (ZRG1-SSS-T (01))
Program Officer
Laughlin, Maren R
Project Start
1994-03-01
Project End
2004-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
7
Fiscal Year
2002
Total Cost
$225,328
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Ellis, F; Nivala, A; Pfaffenbach, K T et al. (2012) C-reactive protein does not impair insulin suppression of glucose release in primary hepatocytes. Nutr Metab Cardiovasc Dis 22:115-9
Gentile, Christopher L; Nivala, Angela M; Gonzales, Jon C et al. (2011) Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease. Am J Physiol Regul Integr Comp Physiol 301:R1710-22
Gentile, Christopher L; Frye, Melinda A; Pagliassotti, Michael J (2011) Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease. Biofactors 37:8-16
Pfaffenbach, Kyle T; Nivala, Angela M; Reese, Lauren et al. (2010) Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver. J Nutr 140:879-84
Pfaffenbach, Kyle T; Gentile, Christopher L; Nivala, Angela M et al. (2010) Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death. Am J Physiol Endocrinol Metab 298:E1027-35
Gentile, C L; Wang, D; Pfaffenbach, K T et al. (2010) Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin. Mol Cell Biochem 344:99-107
Capell, Warren H; Schlaepfer, Isabel R; Wolfe, Pamela et al. (2010) Fatty acids increase glucose uptake and metabolism in C2C12 myoblasts stably transfected with human lipoprotein lipase. Am J Physiol Endocrinol Metab 299:E576-83
Wei, Yuren; Wang, Dong; Gentile, Christopher L et al. (2009) Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells. Mol Cell Biochem 331:31-40
Gentile, Christopher L; Pagliassotti, Michael J (2008) The role of fatty acids in the development and progression of nonalcoholic fatty liver disease. J Nutr Biochem 19:567-76
Gonzales, J C; Gentile, C L; Pfaffenbach, K T et al. (2008) Chemical induction of the unfolded protein response in the liver increases glucose production and is activated during insulin-induced hypoglycaemia in rats. Diabetologia 51:1920-9