Experimental Autoimmune Graves Disease

Prabhakar, Bellur S.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK047417-02
• Application #: 2146996
• Study Section: Immunological Sciences Study Section (IMS)
• Project Start: 1995-06-01
• Project End: 1998-05-31
• Budget Start: 1996-06-01
• Budget End: 1997-05-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: University of Texas Medical Br Galveston
• Department: Microbiology/Immun/Virology
• Type: Schools of Medicine
• DUNS #: 041367053
• City: Galveston
• State: TX
• Country: United States
• Zip Code: 77555

Publications

Martinez, Osvaldo; Gangi, Eryn; Mordi, David et al. (2007) Diversity in the complementarity-determining region 3 (CDR3) of antibodies from mice with evolving anti-thyroid-stimulating hormone receptor antibody responses. Endocrinology 148:752-61

Singh, Surya P; McDonald, David; Hope, Thomas J et al. (2004) Upon thyrotropin binding the thyrotropin receptor is internalized and localized to endosome. Endocrinology 145:1003-10

Gangi, Eryn; Kapatral, Vinayak; El-Azami El-Idrissi, Mohammed et al. (2004) Characterization of a recombinant Yersinia enterocolitica lipoprotein; implications for its role in autoimmune response against thyrotropin receptor. Autoimmunity 37:515-20

Vasu, Chenthamarakshan; Wang, Amy; Gorla, Seema R et al. (2003) CD80 and CD86 C domains play an important role in receptor binding and co-stimulatory properties. Int Immunol 15:167-75

Vasu, Chenthamarakshan; Holterman, Mark J; Prabhakar, Bellur S (2003) Modulation of dendritic cell function and cytokine production to prevent thyroid autoimmunity. Autoimmunity 36:389-96

Vasu, Chenthamarakshan; Dogan, Rukiye-Nazan E; Holterman, Mark J et al. (2003) Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis. J Immunol 170:5511-22

Prasad, Kanteti V; Prabhakar, Bellur S (2003) Apoptosis and autoimmune disorders. Autoimmunity 36:323-30

Dogan, Rukiye-Nazan E; Vasu, Chenthamarakshan; Holterman, Mark J et al. (2003) Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease. J Immunol 170:2195-204

Cundiff, J G; Kaithamana, S; Seetharamaiah, G S et al. (2001) Studies using recombinant fragments of human TSH receptor reveal apparent diversity in the binding specificities of antibodies that block TSH binding to its receptor or stimulate thyroid hormone production. J Clin Endocrinol Metab 86:4254-60

Rao, S; Vasu, C; Martinez, O et al. (2001) Targeted delivery of anti-CTLA-4 antibody downregulates T cell function in vitro and in vivo. Clin Immunol 101:136-45