Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK047499-04
Application #
2147161
Study Section
Special Emphasis Panel (ZRG3-BBCA (01))
Project Start
1993-08-10
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Auckland
Department
Type
DUNS #
City
Auckland
State
Country
New Zealand
Zip Code
1010
Kidd, R D; Baker, H M; Mathews, A J et al. (2001) Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia. Protein Sci 10:1739-49
Kidd, R D; Mathews, A; Baker, H M et al. (2001) Subunit dissociation and reassociation leads to preferential crystallization of haemoglobin Bart's (gamma4) from solutions of human embryonic haemoglobin Portland (zeta2gamma2) at low pH. Acta Crystallogr D Biol Crystallogr 57:921-4
Mathews, A J; Brittain, T (2001) Haem disorder in recombinant- and reticulocyte-derived haemoglobins: evidence for stereoselective haem insertion in eukaryotes. Biochem J 357:305-11
Zheng, T; Brittain, T; Watmough, N J et al. (1999) The role of amino acid alpha38 in the control of oxygen binding to human adult and embryonic haemoglobin Portland. Biochem J 343 Pt 3:681-5
Zheng, T; Zhu, Q; Brittain, T (1999) Origin of the suppression of chloride ion sensitivity in human embryonic hemoglobin Gower II. IUBMB Life 48:435-7
Sutherland-Smith, A J; Baker, H M; Hofmann, O M et al. (1998) Crystal structure of a human embryonic haemoglobin: the carbonmonoxy form of gower II (alpha2 epsilon2) haemoglobin at 2.9 A resolution. J Mol Biol 280:475-84
McLennan, A E; Brittain, T (1998) Non-synergistic interactions between strong allosteric effectors and human embryonic and adult haemoglobins. Biochem Mol Biol Int 44:175-83
Hofmann, O M; Brittain, T (1998) Partitioning of oxygen and carbon monoxide in the three human embryonic hemoglobins. Hemoglobin 22:313-9
Brittain, T; Hofmann, O M; Watmough, N J et al. (1997) A two-state analysis of co-operative oxygen binding in the three human embryonic haemoglobins. Biochem J 326 ( Pt 2):299-303
Hofmann, O M; Brittain, T; Wells, R M (1997) The control of oxygen affinity in the three human embryonic haemoglobins by respiration linked metabolites. Biochem Mol Biol Int 42:553-66

Showing the most recent 10 out of 17 publications