Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK048028-01A2
Application #
2016815
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1996-09-15
Project End
1997-08-31
Budget Start
1996-09-15
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Xu, Lingfei; Mei, Manxue; Haskins, Mark E et al. (2007) Immune response after neonatal transfer of a human factor IX-expressing retroviral vector in dogs, cats, and mice. Thromb Res 120:269-80
Xu, L; Mei, M; Ma, X et al. (2007) High expression reduces an antibody response after neonatal gene therapy with B domain-deleted human factor VIII in mice. J Thromb Haemost 5:1805-12
Xu, Lingfei; Nichols, Timothy C; Sarkar, Rita et al. (2005) Absence of a desmopressin response after therapeutic expression of factor VIII in hemophilia A dogs with liver-directed neonatal gene therapy. Proc Natl Acad Sci U S A 102:6080-5
Zhang, Jun; Xu, Lingfei; Haskins, Mark E et al. (2004) Neonatal gene transfer with a retroviral vector results in tolerance to human factor IX in mice and dogs. Blood 103:143-51
Xu, Lingfei; Gao, Cuihua; Sands, Mark S et al. (2003) Neonatal or hepatocyte growth factor-potentiated adult gene therapy with a retroviral vector results in therapeutic levels of canine factor IX for hemophilia B. Blood 101:3924-32
Xu, Lingfei; Haskins, Mark E; Melniczek, John R et al. (2002) Transduction of hepatocytes after neonatal delivery of a Moloney murine leukemia virus based retroviral vector results in long-term expression of beta-glucuronidase in mucopolysaccharidosis VII dogs. Mol Ther 5:141-53
Xu, L; Daly, T; Gao, C et al. (2001) CMV-beta-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 alpha promoter and results in therapeutic levels of human factor X in mice. Hum Gene Ther 12:563-73
Gao, C; Kennedy, S; Ponder, K P (2001) Lipopolysaccharide potentiates the effect of hepatocyte growth factor upon replication in lung, thyroid, spleen, and colon in rats in vivo. Mol Ther 3:462-75
Gao, C; Sands, M S; Haskins, M E et al. (2000) Delivery of a retroviral vector expressing human beta-glucuronidase to the liver and spleen decreases lysosomal storage in mucopolysaccharidosis VII mice. Mol Ther 2:233-44
Gao, C; Jokerst, R; Gondipalli, P et al. (1999) Lipopolysaccharide potentiates the effect of hepatocyte growth factor on hepatocyte replication in rats by augmenting AP-1 activity. Hepatology 30:1405-16

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