Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK048216-03
Application #
2148363
Study Section
Endocrinology Study Section (END)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1998-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Fantin, V R; Wang, Q; Lienhard, G E et al. (2000) Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am J Physiol Endocrinol Metab 278:E127-33
Chazenbalk, G D; Wang, Y; Guo, J et al. (1999) A mouse monoclonal antibody to a thyrotropin receptor ectodomain variant provides insight into the exquisite antigenic conformational requirement, epitopes and in vivo concentration of human autoantibodies. J Clin Endocrinol Metab 84:702-10
Tanaka, K; Chazenbalk, G D; McLachlan, S M et al. (1999) The shed thyrotropin receptor is primarily a carboxyl terminal truncated form of the A subunit, not the entire A subunit. Mol Cell Endocrinol 150:113-9
Jaume, J C; Rapoport, B; McLachlan, S M (1999) Lack of female bias in a mouse model of autoimmune hyperthyroidism (Graves' disease). Autoimmunity 29:269-72
Tanaka, K; Chazenbalk, G D; McLachlan, S M et al. (1998) Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion. J Biol Chem 273:1959-63
Kakinuma, A; Portolano, S; Chazenbalk, G et al. (1997) Insight into screening immunoglobulin gene combinatorial libraries in a phage display vector: a tale of two antibodies. Autoimmunity 25:73-84
Chazenbalk, G D; Tanaka, K; Nagayama, Y et al. (1997) Evidence that the thyrotropin receptor ectodomain contains not one, but two, cleavage sites. Endocrinology 138:2893-9
Guo, J; Rapoport, B; McLachlan, S M (1997) Thyroid peroxidase autoantibodies of IgE class in thyroid autoimmunity. Clin Immunol Immunopathol 82:157-62
Jaume, J C; Kakinuma, A; Chazenbalk, G D et al. (1997) Thyrotropin receptor autoantibodies in serum are present at much lower levels than thyroid peroxidase autoantibodies: analysis by flow cytometry. J Clin Endocrinol Metab 82:500-7
Farrar, J; Portolano, S; Willcox, N et al. (1997) Diverse Fab specific for acetylcholine receptor epitopes from a myasthenia gravis thymus combinatorial library. Int Immunol 9:1311-8

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