Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK048283-03
Application #
2148474
Study Section
Endocrinology Study Section (END)
Project Start
1994-07-11
Project End
1999-06-30
Budget Start
1996-07-24
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Physiology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Stofega, M R; Herrington, J; Billestrup, N et al. (2000) Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B. Mol Endocrinol 14:1338-50
Stofega, M R; Argetsinger, L S; Wang, H et al. (2000) Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. J Biol Chem 275:28222-9
Carter-Su, C; Rui, L; Herrington, J (2000) Role of the tyrosine kinase JAK2 in signal transduction by growth hormone. Pediatr Nephrol 14:550-7
Stofega, M R; Wang, H; Ullrich, A et al. (1998) Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association. J Biol Chem 273:7112-7
Campbell, G S; Yu, C L; Jove, R et al. (1997) Constitutive activation of JAK1 in Src-transformed cells. J Biol Chem 272:2591-4
Argetsinger, L S; Carter-Su, C (1996) Mechanism of signaling by growth hormone receptor. Physiol Rev 76:1089-107
Carter-Su, C; King, A P; Argetsinger, L S et al. (1996) Signalling pathway of GH. Endocr J 43 Suppl:S65-70
King, A P; Tseng, M J; Logsdon, C D et al. (1996) Distinct cytoplasmic domains of the growth hormone receptor are required for glucocorticoid- and phorbol ester-induced decreases in growth hormone (GH) binding. These domains are different from that reported for GH-induced receptor internalization. J Biol Chem 271:18088-94
VanderKuur, J A; Wang, X; Zhang, L et al. (1995) Growth hormone-dependent phosphorylation of tyrosine 333 and/or 338 of the growth hormone receptor. J Biol Chem 270:21738-44
King, A P; Carter-Su, C (1995) Dexamethasone-induced antagonism of growth hormone (GH) action by down-regulation of GH binding in 3T3-F442A fibroblasts. Endocrinology 136:4796-803