Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK048423-02
Application #
2148705
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1995-06-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Biochemistry
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Nilakantan, Vani; Halligan, Nadine L N; Nguyen, Thanh K et al. (2005) Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthase. J Heart Lung Transplant 24:1591-9
Pieper, Galen M; Nilakantan, Vani; Hilton, Gail et al. (2004) Variable efficacy of N6-(1-iminoethyl)-L-lysine in acute cardiac transplant rejection. Am J Physiol Heart Circ Physiol 286:H525-34
Bretscher, Lynn E; Li, Huiying; Poulos, Thomas L et al. (2003) Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines. J Biol Chem 278:46789-97
Pieper, Galen M; Halligan, Nadine L N; Hilton, Gail et al. (2003) Non-heme iron protein: a potential target of nitric oxide in acute cardiac allograft rejection. Proc Natl Acad Sci U S A 100:3125-30
Raman, C S; Li, H; Martasek, P et al. (2001) Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase. J Biol Chem 276:26486-91
Shi, Y; Pritchard Jr, K A; Holman, P et al. (2000) Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. Free Radic Biol Med 29:695-703
Babu, B R; Frey, C; Griffith, O W (1999) L-arginine binding to nitric-oxide synthase. The role of H-bonds to the nonreactive guanidinium nitrogens. J Biol Chem 274:25218-26
Babu, B R; Griffith, O W (1998) Design of isoform-selective inhibitors of nitric oxide synthase. Curr Opin Chem Biol 2:491-500
Babu, B R; Griffith, O W (1998) N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem 273:8882-9
Spack, L; Havens, P L; Griffith, O W (1997) Measurements of total plasma nitrite and nitrate in pediatric patients with the systemic inflammatory response syndrome. Crit Care Med 25:1071-8

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