Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK048503-01
Application #
2148846
Study Section
Nutrition Study Section (NTN)
Project Start
1994-09-01
Project End
1997-08-31
Budget Start
1994-09-01
Budget End
1995-08-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215
Wang, P H; Almahfouz, A; Giorgino, F et al. (1999) In vivo insulin signaling in the myocardium of streptozotocin-diabetic rats: opposite effects of diabetes on insulin stimulation of glycogen synthase and c-Fos. Endocrinology 140:1141-50
Qu, Z; Ling, P R; Chow, J C et al. (1998) Effects of dietary protein and tumor necrosis factor on components of the insulin-like growth factor-I pathway in the colon and small intestine in protein-depleted rats. Metabolism 47:345-50
Ziegler, T R; Mantell, M P; Chow, J C et al. (1998) Intestinal adaptation after extensive small bowel resection: differential changes in growth and insulin-like growth factor system messenger ribonucleic acids in jejunum and ileum. Endocrinology 139:3119-26
Qu, Z; Chow, J C; Ling, P R et al. (1997) Tissue-specific effects of chronic dietary protein restriction and gastrostomy on the insulin-like growth factor-I pathway in the liver and colon of adult rats. Metabolism 46:691-7
Giorgino, F; Pedrini, M T; Matera, L et al. (1997) Specific increase in p85alpha expression in response to dexamethasone is associated with inhibition of insulin-like growth factor-I stimulated phosphatidylinositol 3-kinase activity in cultured muscle cells. J Biol Chem 272:7455-63
Porch, J V; Jain, K; Reilly, A et al. (1997) Aging, physical activity, insulin-like growth factor I, and body composition in Guatemalan women. Am J Clin Nutr 66:874-9
Ziegler, T R; Mantell, M P; Chow, J C et al. (1996) Gut adaptation and the insulin-like growth factor system: regulation by glutamine and IGF-I administration. Am J Physiol 271:G866-75
Chow, J C; Ling, P R; Qu, Z et al. (1996) Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo. Endocrinology 137:2880-6
Giorgino, F; Smith, R J (1995) Dexamethasone enhances insulin-like growth factor-I effects on skeletal muscle cell proliferation. Role of specific intracellular signaling pathways. J Clin Invest 96:1473-83
Mantell, M P; Ziegler, T R; Adamson, W T et al. (1995) Resection-induced colonic adaptation is augmented by IGF-I and associated with upregulation of colonic IGF-I mRNA. Am J Physiol 269:G974-80

Showing the most recent 10 out of 11 publications