Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK049045-02
Application #
2149610
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Temple University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Le, Quan; Soprano, Dianne Robert; Soprano, Kenneth J (2002) Profiling of retinoid mediated gene expression in synchronized human SCC cells using Atlas human cDNA expression arrays. J Cell Physiol 190:345-55
Zhang, D; Vuocolo, S; Masciullo, V et al. (2001) Cell cycle genes as targets of retinoid induced ovarian tumor cell growth suppression. Oncogene 20:7935-44
Duker, N J; Sperling, J; Soprano, K J et al. (2001) beta-Amyloid protein induces the formation of purine dimers in cellular DNA. J Cell Biochem 81:393-400
Holmes, W F; Dawson, M I; Soprano, R D et al. (2000) Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. J Cell Physiol 185:61-7
Le, Q; Dawson, M I; Soprano, D R et al. (2000) Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene 19:1457-65
Zhang, D; Holmes, W F; Wu, S et al. (2000) Retinoids and ovarian cancer. J Cell Physiol 185:20-Jan
Wu, S; Zhang, D; Zhang, Z P et al. (1998) Critical role of both retinoid nuclear receptors and retinoid-X-receptors in mediating growth inhibition of ovarian cancer cells by all-trans retinoic acid. Oncogene 17:2839-49
Wu, S; Zhang, D; Donigan, A et al. (1998) Effects of conformationally restricted synthetic retinoids on ovarian tumor cell growth. J Cell Biochem 68:378-88
Wu, S; Donigan, A; Platsoucas, C D et al. (1997) All-trans-retinoic acid blocks cell cycle progression of human ovarian adenocarcinoma cells at late G1. Exp Cell Res 232:277-86
Wu, S; Zhang, Z P; Zhang, D et al. (1997) Reduction of both RAR and RXR levels is required to maximally alter sensitivity of CA-OV3 ovarian tumor cells to growth suppression by all-trans-retinoic acid. Exp Cell Res 237:118-26

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